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Programmes/ Projects Supported by ATF

2011

Programmes / Projects supported by the AIDS Trust Fund in January 2011

MSS 186 R
Application: Study on the contribution of HIV-1 CRF-01_AE specific pol polymorphisms to the antiretroviral drug resistance through the use of an in-house phenotypic resistance assay
(Executive Summary submitted by the applicant)
Applicant: Department of Microbiology, The University of Hong Kong
Objectives: The objectives of this programme are:-
  1. Developing an in-house phenotypic drug resistance assay for measuring the drug susceptibilities of currently available PIs, NRTIs and NNRTIs
  2. Verifying the phenotypic drug susceptibility on clinical HIV/AIDS patients who demonstrated clinical failure but without defined viral genotypic drug resistance mutations; and
  3. Identifying the influence of the CRF01_AE-specific polymorphisms to the genetic barrier for the virus to develop antiretroviral drug resistance on available PIs, NRTIs and NNRTIs in Hong Kong.
Project Duration: April 2011 to March 2013
Contact Person: Dr. Jonathan Hon Kwan CHEN
Post-doctoral Fellow
Department of Microbiology,
University Pathology Building,
Queen Mary Hospital Compound,
The University of Hong Kong,
Pokfulam,
HONG KONG
Telephone: 2819 9703
Fax: 2255 1241